Gene Delivery to Human Limbal Stem Cells Using Viral Vectors
نویسندگان
چکیده
منابع مشابه
Gene Delivery to Mesenchymal Stem Cells
There is increasing trend in using recombinant stem cells as novel therapeutic candidates in different diseases. These studies encompass different applications from targeted homing of Mesenchymal Stromal (stem) Cells (MSC), to arming them with different cytokines. Resistance to transfection or transduction methods had urged researchers to look for better gene delivery alternates and optimizing ...
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Hematopoietic stem cells (HSCs) are clonogenic cells capable of both selfrenewal and multilineage differentiation. An efficient method for gene transfer into HSCs is required for exploring HSC biology as well as for gene therapy of hematopoietic disorders. Retroviral vectors have been the most widely used vectors for gene transfer to HSCs. However, retroviral vectors require cell division for i...
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The Sleeping Beauty (SB) transposon system is a non-viral gene delivery platform that combines simplicity, inexpensive manufacture, and favorable safety features in the context of human applications. However, efficient correction of hematopoietic stem and progenitor cells (HSPCs) with non-viral vector systems, including SB, demands further refinement of gene delivery techniques. We set out to i...
متن کاملgene delivery to mesenchymal stem cells
there is increasing trend in using recombinant stem cells as novel therapeutic candidates in different diseases. these studies encompass different applications from targeted homing of mesenchymal stromal (stem) cells (msc), to arming them with different cytokines. resistance to transfection or transduction methods had urged researchers to look for better gene delivery alternates and optimizing ...
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ژورنال
عنوان ژورنال: Human Gene Therapy
سال: 2019
ISSN: 1043-0342,1557-7422
DOI: 10.1089/hum.2019.071